The only bus we could consider direct from the airport to the center is the one going from the airport and terminating at Hlavni Nadrazi (Main Train Station, line C). Main Train Station is close to the city center, so you can use this option, but note that this service is operated by Czech Railways, and the cost is slightly higher, 100 CZK.
When departing Prague from Staromestska Metro Station (green Line) to Nadrazi Veleslavin then Bus 119 to Airport allow 40 minutes for the journey. By Train. Prague has two main railway stations. Praha Hlavni Nádraží (Main Station in Czech) is located almost in the city center.
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how to get from prague airport to train station